SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams.

@article{Gutmann1989SHV5AN,
  title={SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams.},
  author={L. Gutmann and B. Ferr{\'e} and F. Goldstein and N. Rizk and E. Pinto-Schuster and J. Acar and E. Collatz},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1989},
  volume={33},
  pages={951 - 956}
}
SHV-5 (pI 8.2), a novel broad-spectrum beta-lactamase encoded by a ca. 150-kilobase plasmid, was found in Klebsiella pneumoniae 160. SHV-5 beta-lactamase caused decreased susceptibility to most penicillins, cephalosporins, and monobactams, except imipenem and compounds which have a C6 or C7 alpha-methoxy substituent. beta-Lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) inhibited its activity and showed a synergistic effect when associated with different hydrolyzable beta… Expand
117 Citations
Biochemical Characterization of SHV-55, an Extended-Spectrum Class A β-Lactamase from Klebsiella pneumoniae
  • 4
  • PDF
Evolution and spread of SHV extended-spectrum beta-lactamases in gram-negative bacteria.
  • 128
  • PDF
A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous
  • 76
Origin and impact of plasmid-mediated extended-spectrum beta-lactamases
  • 75
Extended-spectrum beta-lactamases.
  • 716
  • PDF
Epidemiology of Extended-Spectrum β-Lactamases in Sofia, Bulgaria
  • 11
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase inhibitors.
  • 126
  • PDF
Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.
  • 103
  • Highly Influential
Behaviour of TEM-1 beta-lactamase as a resistance mechanism to ampicillin, mezlocillin and azlocillin in Escherichia coli.
  • 19
Evolution of plasmid-coded resistance to broad-spectrum cephalosporins.
  • 412
  • Highly Influential
  • PDF
Novel plasmid-mediated beta-lactamase in clinical isolates of Klebsiella pneumoniae more resistant to ceftazidime than to other broad-spectrum cephalosporins.
  • 104
  • PDF
Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.
  • 372
In vitro evaluation of tigemonam, a novel oral monobactam.
  • 31
  • PDF
Plasmid-mediated resistance to third-generation cephalosporins caused by point mutations in TEM-type penicillinase genes.
  • 169
  • Highly Influential
Cross-resistance to nalidixic acid, trimethoprim, and chloramphenicol associated with alterations in outer membrane proteins of Klebsiella, Enterobacter, and Serratia.
  • 186
...
1
2
3
...