SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer.

@article{Gu2014SHP2PL,
  title={SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer.},
  author={Jia Gu and Tao Han and Ruiting Ma and Yu-Lin Zhu and Yi-Na Jia and Jing-jing Du and Yu Chen and Xue-jun Jiang and Xiao-dong Xie and Xingqi Guo},
  journal={International journal of oncology},
  year={2014},
  volume={44 2},
  pages={
          481-90
        }
}
The overall survival rate and prognosis of patients with laryngeal cancer are not optimistic despite advances in therapeutic techniques. Gene expression prognostic models enable the development of more appropriate treatment strategies. The human gene PTPN11 encoding a non-receptor protein tyrosine phosphatase, Src homology phosphotyrosine phosphatase 2 (SHP2), is a well-documented proto-oncogene in various malignancies. This study investigated the role of SHP2 expression and associated clinical… 
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