SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin, dephosphorylation of FAK and secretion of MMP-9 induced by IL-1 βin vivo andin vitro

@article{Wang2004SHP2PM,
  title={SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin, dephosphorylation of FAK and secretion of MMP-9 induced by IL-1 βin vivo andin vitro},
  author={Feng-mei Wang and Hou-qi Liu and Shan-rong Liu and Shu-ping Tang and Ling Yang and Gen-sheng Feng},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={89},
  pages={5-14}
}
Shp-2, an src homology (SH) two-containing phosphotyrosine phosphatase, appears to be involved in cytoplasmic signaling downstream of a variety of cell surface receptors. It also plays an important role in the control of cell spreading, migration, and cytoskeletal architecture. In our study, abrogation of SHP-2 catalytic activity with a’dominant-negative mutant (SHP-2C>S) displayed an increased number of focal adhesion, high expression of E-cadhenrin and phosphorylation of the focal adhesion… CONTINUE READING
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