SHP-2 and myeloid malignancies.

  title={SHP-2 and myeloid malignancies.},
  author={M Tartaglia and Charlotte Marie Niemeyer and Kevin M. Shannon and Mignon L Loh},
  journal={Current opinion in hematology},
  volume={11 1},
PURPOSE OF REVIEW This review focuses on the non-receptor Src-homology 2 domain-containing protein tyrosine phosphatase SHP-2 and its role in signal transduction, hematopoiesis, and leukemogenesis. Specifically, we discuss the role of inherited and somatic mutations that result in SHP-2 gain-of-function in human disease, including myeloid malignancies. RECENT FINDINGS Up-regulation of RAS signaling is a major perturbation that drives the aberrant growth of malignant myeloid cells. Leukemia… CONTINUE READING