SHP-1 is a target of regorafenib in colorectal cancer

  title={SHP-1 is a target of regorafenib in colorectal cancer},
  author={Li-Ching Fan and H. Teng and C. Shiau and H. Lin and Man-Hsin Hung and Y. Chen and Jui-Wen Huang and Wei-Tien Tai and Hui-Chuan Yu and K. Chen},
  pages={6243 - 6251}
  • Li-Ching Fan, H. Teng, +7 authors K. Chen
  • Published 2014
  • Medicine
  • Oncotarget
  • Regorafenib is an inhibitor of multiple protein kinases which exerts antitumor and antimetastatic activities in metastatic colorectal cancer (CRC). SH2 domain-containing phosphatase 1 (SHP-1) is reported to have tumor suppressive potential because it acts as a negative regulator of p-STAT3Tyr705 signaling. However, little is known about the mechanism regarding regorafenib affects SHP-1 tyrosine phosphatase activity and leads to apoptosis and tumor suppression in CRC. Here, we found that… CONTINUE READING
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