SHP-1 is a target of regorafenib in colorectal cancer

@inproceedings{Fan2014SHP1IA,
  title={SHP-1 is a target of regorafenib in colorectal cancer},
  author={Li-Ching Fan and Michael Mu-Hou Teng and Chii Shinn Shiau and Hang Lin and Man‐Hsin Hung and Yen-Lin Chen and Jianping Huang and Wai Ting Tai and Hui-Chuan Yu and Kuen-Feng Chen},
  booktitle={Oncotarget},
  year={2014}
}
Regorafenib is an inhibitor of multiple protein kinases which exerts antitumor and antimetastatic activities in metastatic colorectal cancer (CRC). SH2 domain-containing phosphatase 1 (SHP-1) is reported to have tumor suppressive potential because it acts as a negative regulator of p-STAT3(Tyr705) signaling. However, little is known about the mechanism regarding regorafenib affects SHP-1 tyrosine phosphatase activity and leads to apoptosis and tumor suppression in CRC. Here, we found that… CONTINUE READING
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