SHP-1 is a target of regorafenib in colorectal cancer

@article{Fan2014SHP1IA,
  title={SHP-1 is a target of regorafenib in colorectal cancer},
  author={Li-Ching Fan and H. Teng and C. Shiau and H. Lin and Man-Hsin Hung and Y. Chen and Jui-Wen Huang and Wei-Tien Tai and Hui-Chuan Yu and K. Chen},
  journal={Oncotarget},
  year={2014},
  volume={5},
  pages={6243 - 6251}
}
  • Li-Ching Fan, H. Teng, +7 authors K. Chen
  • Published 2014
  • Medicine
  • Oncotarget
  • Regorafenib is an inhibitor of multiple protein kinases which exerts antitumor and antimetastatic activities in metastatic colorectal cancer (CRC). SH2 domain-containing phosphatase 1 (SHP-1) is reported to have tumor suppressive potential because it acts as a negative regulator of p-STAT3Tyr705 signaling. However, little is known about the mechanism regarding regorafenib affects SHP-1 tyrosine phosphatase activity and leads to apoptosis and tumor suppression in CRC. Here, we found that… CONTINUE READING
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    References

    SHOWING 1-10 OF 28 REFERENCES
    The function of the protein tyrosine phosphatase SHP-1 in cancer.
    • 259
    Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity.
    • 56
    Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells
    • 50
    SHP‐1 suppresses cancer cell growth by promoting degradation of JAK kinases
    • 85
    Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
    • 106
    • PDF
    SHP-1 in cell-cycle regulation.
    • 64
    Regorafenib (BAY 73-4506): Antitumor and antimetastatic activities in preclinical models of colorectal cancer
    • 70
    A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation.
    • 39
    Molecular mechanisms underlying SHP-1 gene expression.
    • 39