SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein.


β-catenin plays a dual role both as a key effector in the regulation of adherens junctions and as a transcriptional coactivator. Tyrosine phosphorylation of β-catenin is implicated as a means for its release from E-cadherin complexes and correlates with enhanced transcriptional activity. However, it remains unclear whether or not tyrosine phosphorylated… (More)
DOI: 10.1016/j.cellsig.2010.09.011


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