SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development.

@article{Blaschke1998SHOTAS,
  title={SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development.},
  author={Rudiger J Blaschke and A. Paula Monaghan and Simone Schiller and Birgit Schechinger and E. V. C. Sekhara Rao and Hesed M. Padilla-Nash and Thomas Ried and Gudrun A Rappold},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 5},
  pages={2406-11}
}
Deletion of the SHOX region on the human sex chromosomes has been shown to result in idiopathic short stature and proposed to play a role in the short stature associated with Turner syndrome. We have identified a human paired-related homeobox gene, SHOT, by virtue of its homology to the human SHOX and mouse OG-12 genes. Two different isoforms were isolated, SHOTa and SHOTb, which have identical homeodomains and share a C-terminal 14-amino acid residue motif characteristic for craniofacially… CONTINUE READING
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