SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer

@inproceedings{Komlsi2010SHMT11A,
  title={SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer},
  author={Viktor L. Koml{\'o}si and Erika Hitre and {\'E}va Pap and Vilmos Adleff and Andrea R{\'e}ti and {\'E}va Sz{\'e}kely and Anna B{\'i}r{\'o} and P{\'e}ter Rudnai and Bernadette Schoket and Judit M{\"u}ller and B T{\'o}th and Szabolcs Ott{\'o} and Mikl{\'o}s K{\'a}sler and Judit Kralov{\'a}nszky and Barna Budai},
  booktitle={BMC Cancer},
  year={2010}
}
Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. The SHMT1 and MTHFR genotypes were determined by real-time PCR and PCR-RFLP, respectively in 476 patients with rectal, 479 patients with colon cancer and in 461 and 478, respective controls matched for age and sex. Homocysteine… CONTINUE READING