SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells

@article{Tokue2017SHISA6CR,
  title={SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells},
  author={Moe Tokue and Kanako Ikami and S. Mizuno and C. Takagi and Asuka Miyagi and R. Takada and C. Noda and Yu Kitadate and K. Hara and Hiroko Mizuguchi and T. Sato and M. Taketo and F. Sugiyama and T. Ogawa and S. Kobayashi and N. Ueno and S. Takahashi and S. Takada and S. Yoshida},
  journal={Stem Cell Reports},
  year={2017},
  volume={8},
  pages={561 - 575}
}
  • Moe Tokue, Kanako Ikami, +16 authors S. Yoshida
  • Published 2017
  • Biology, Medicine
  • Stem Cell Reports
  • Summary In the seminiferous tubules of mouse testes, a population of glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRα1)-positive spermatogonia harbors the stem cell functionality and supports continual spermatogenesis, likely independent of asymmetric division or definitive niche control. Here, we show that activation of Wnt/β-catenin signaling promotes spermatogonial differentiation and reduces the GFRα1+ cell pool. We further discovered that SHISA6 is a cell… CONTINUE READING
    30 Citations

    Figures and Topics from this paper

    Identification of EOMES-expressing spermatogonial stem cells and their regulation by PLZF
    • 13
    • Highly Influenced
    Wnt/β‐catenin signaling enhances transcription of the CX43 gene in murine Sertoli cells
    • 3
    Regulation of GDNF expression in Sertoli cells.
    • 9
    • PDF
    Open niche regulation of mouse spermatogenic stem cells
    • S. Yoshida
    • Biology, Medicine
    • Development, growth & differentiation
    • 2018
    • 16

    References

    SHOWING 1-10 OF 83 REFERENCES
    Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis
    • 70
    • Highly Influential
    • PDF
    Indirect Effects of Wnt3a/β-Catenin Signalling Support Mouse Spermatogonial Stem Cells In Vitro
    • 46
    • PDF
    Wnt5a is a cell-extrinsic factor that supports self-renewal of mouse spermatogonial stem cells
    • 91
    • PDF
    FGF8-FGFR1 Signaling Acts as a Niche Factor for Maintaining Undifferentiated Spermatogonia in the Mouse1
    • 28
    • PDF
    GDNF‐mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells
    • 71
    Spermatogonial Stem Cell Self-Renewal Requires ETV5-Mediated Downstream Activation of Brachyury in Mice1
    • 82
    • PDF
    Functional and molecular features of the Id4+ germline stem cell population in mouse testes.
    • 151
    • Highly Influential
    • PDF
    CDH1 Is a Specific Marker for Undifferentiated Spermatogonia in Mouse Testes1
    • 192
    • PDF