SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells

  title={SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells},
  author={Moe Tokue and Kanako Ikami and S. Mizuno and C. Takagi and Asuka Miyagi and R. Takada and C. Noda and Yu Kitadate and K. Hara and Hiroko Mizuguchi and T. Sato and M. Taketo and F. Sugiyama and T. Ogawa and S. Kobayashi and N. Ueno and S. Takahashi and S. Takada and S. Yoshida},
  journal={Stem Cell Reports},
  pages={561 - 575}
  • Moe Tokue, Kanako Ikami, +16 authors S. Yoshida
  • Published 2017
  • Biology, Medicine
  • Stem Cell Reports
  • Summary In the seminiferous tubules of mouse testes, a population of glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRα1)-positive spermatogonia harbors the stem cell functionality and supports continual spermatogenesis, likely independent of asymmetric division or definitive niche control. Here, we show that activation of Wnt/β-catenin signaling promotes spermatogonial differentiation and reduces the GFRα1+ cell pool. We further discovered that SHISA6 is a cell… CONTINUE READING
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