SHARPs: MammalianEnhancer-of-Split- andHairy-Related Proteins Coupled to Neuronal Stimulation

@article{Rossner1997SHARPsMA,
  title={SHARPs: MammalianEnhancer-of-Split- andHairy-Related Proteins Coupled to Neuronal Stimulation},
  author={Moritz J. Rossner and Jochen D{\"o}rr and Peter Gass and Markus H. Schwab and Klaus-Armin Nave},
  journal={Molecular and Cellular Neuroscience},
  year={1997},
  volume={9},
  pages={460-475}
}
In the mammalian central nervous system, a diverse group of basic helix-loop-helix (bHLH) proteins is involved in the determination of progenitor cells and, subsequently, in regulating neuronal differentiation. Here we report the identification of a novel subfamily of bHLH proteins, defined by two mammalian enhancer-of-split- and hairy-related proteins, termed SHARP-1 and SHARP-2. In contrast to known bHLH genes, detectable transcription of SHARP genes begins at the end of embryonic development… 
Stra13 and Sharp-1, the non-grouchy regulators of development and disease.
Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins.
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The identification and characterization of human, mouse and rat DEC2, a novel member of the DEC subfamily that showed a more restricted pattern of mRNA expression and may play an important role in tissue development.
bHLH-Orange Transcription Factors in Development and Cancer
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The structure and biological functions of bHLH-O factors are reviewed, and recent studies that suggest a potential role for these factors in tumorigenesis and tumor progression are discussed.
The Basic Helix-Loop-Helix Protein, SHARP-1, Represses Transcription by a Histone Deacetylase-dependent and Histone Deacetylase-independent Mechanism*
TLDR
This study is the first report to assign a function to, and to identify a target gene for, the bHLH transcription factor SHARP-1, and identifies two independent repression domains that operate via distinct mechanisms.
Gene Expression of Basic Helix-Loop-Helix Transcription Factor, SHARP-2, Is Regulated by Gonadotropins in the Rat Ovary and MA-10 Cells1
TLDR
The level of SHarp-2 mRNA is regulated by gonadotropins and that SHARP-2 functions as a transcriptional repressor localized in the nucleus, which is concluded to be a bHLH protein family member.
Sharp-1/DEC2 Inhibits Skeletal Muscle Differentiation through Repression of Myogenic Transcription Factors*
TLDR
It is reported here that endogenous Sharp-1 is expressed in proliferating C2C12 myoblasts and is down-regulated during myogenic differentiation, and it is demonstrated that the interaction ofSharp-1 with MyoD and E-proteins results in reduced DNA binding and transactivation from MyOD-dependent E-box sites.
Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway.
TLDR
It is suggested that DEC1 is a novel direct target for cAMP in wide types of cells, and that the bHLH protein is involved in the control of gene expression in cAMP-activated cells.
Insulin stimulates the expression of the SHARP-1 gene via multiple signaling pathways.
  • K. TakagiK. Asano K. Yamada
  • Biology
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2014
TLDR
It is concluded that insulin induces the SHARP-1 gene expression at the transcription level via a both PI 3-K/aPKCλ/JNK- and a PI 3/Rac/J NK-signaling pathway; protein synthesis is required for this induction; and that SHarp-1 is a potential repressor of the PEPCK gene expression.
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