SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

@article{Ikeda2011SHARPINFA,
  title={SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis},
  author={F. Ikeda and Yonathan Lissanu Deribe and Sigrid S. Sk{\aa}nland and B. Stieglitz and C. Grabbe and M. Franz‐Wachtel and S. J. V. Wijk and P. Goswami and V. Nagy and J. Terzi{\'c} and F. Tokunaga and A. Androulidaki and T. Nakagawa and M. Pasparakis and K. Iwai and J. Sundberg and L. Schaefer and K. Rittinger and B. Macek and I. Dikic},
  journal={Nature},
  year={2011},
  volume={471},
  pages={637-641}
}
  • F. Ikeda, Yonathan Lissanu Deribe, +17 authors I. Dikic
  • Published 2011
  • Biology, Medicine
  • Nature
  • SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system disorders and multi-organ inflammation. Here we report that SHARPIN functions as a novel component of the linear ubiquitin chain assembly complex (LUBAC) and that the absence of SHARPIN causes dysregulation of NF-κB and apoptotic signalling pathways, explaining the severe phenotypes displayed by chronic proliferative dermatitis (cpdm) in SHARPIN-deficient mice. Upon… CONTINUE READING
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