SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

  title={SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis},
  author={F. Ikeda and Yonathan Lissanu Deribe and Sigrid S. Sk{\aa}nland and B. Stieglitz and C. Grabbe and M. Franz‐Wachtel and S. J. V. Wijk and P. Goswami and V. Nagy and J. Terzi{\'c} and F. Tokunaga and A. Androulidaki and T. Nakagawa and M. Pasparakis and K. Iwai and J. Sundberg and L. Schaefer and K. Rittinger and B. Macek and I. Dikic},
  • F. Ikeda, Yonathan Lissanu Deribe, +17 authors I. Dikic
  • Published 2011
  • Biology, Medicine
  • Nature
  • SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system disorders and multi-organ inflammation. Here we report that SHARPIN functions as a novel component of the linear ubiquitin chain assembly complex (LUBAC) and that the absence of SHARPIN causes dysregulation of NF-κB and apoptotic signalling pathways, explaining the severe phenotypes displayed by chronic proliferative dermatitis (cpdm) in SHARPIN-deficient mice. Upon… CONTINUE READING
    Ubiquitination in signaling to and activation of IKK
    • 291
    • PDF
    The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
    • 258
    • Highly Influenced
    OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin
    • 254
    • Highly Influenced
    • PDF
    A20 inhibits LUBAC‐mediated NF‐κB activation by binding linear polyubiquitin chains via its zinc finger 7
    • 160
    • PDF
    NF-κB, the first quarter-century: remarkable progress and outstanding questions.
    • 1,182
    • Highly Influenced
    • PDF
    Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis
    • 106
    • PDF
    Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
    • 253
    • PDF


    Publications referenced by this paper.
    A ubiquitin ligase complex assembles linear polyubiquitin chains
    • 601
    • PDF
    Atypical ubiquitin chains: new molecular signals
    • 917
    • PDF