SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

Abstract

Genetic mutations of SHANK3 have been reported in patients with intellectual disability, autism spectrum disorder (ASD) and schizophrenia. At the synapse, Shank3/ProSAP2 is a scaffolding protein that connects glutamate receptors to the actin cytoskeleton via a chain of intermediary elements. Although genetic studies have repeatedly confirmed the association… (More)
DOI: 10.1038/mp.2011.57

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