SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload.

@article{Wu2015SH2B1IC,
  title={SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload.},
  author={Gang Wu and Yu Liu and He Huang and Yanhong Tang and Wanli Liu and Yang Yan Mei and Nian Wan and Xiaoxiong Liu and Cong-xin Huang},
  journal={Cardiovascular research},
  year={2015},
  volume={107 2},
  pages={203-15}
}
AIMS Src homology 2 (SH2) B adaptor protein 1 (SH2B1) is expressed in various tissues, including the heart. Previous studies have demonstrated that SH2B1 is involved in a variety of biological process, such as maintaining neuronal differentiation, regulating energy and glucose homeostasis, and promoting cell proliferation and motility. However, the role of SH2B1 in cardiac hypertrophy remains unclear. This study aimed at identifying the effects and the underlying mechanisms of SH2B1 in cardiac… CONTINUE READING

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