SH2-B is required for both male and female reproduction.

  title={SH2-B is required for both male and female reproduction.},
  author={Satoshi Ohtsuka and Satoshi Takaki and Masanori Iseki and Kanta Miyoshi and Naomi Nakagata and Yuki Kataoka and Nobuaki Yoshida and Kiyoshi Takatsu and Akihiko Yoshimura},
  journal={Molecular and cellular biology},
  volume={22 9},
Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been shown to interact with insulin and IGF-I receptors, although the role of SH2-B in these signals has not been clarified. To investigate the role of SH2-B, we generated mice with a targeted disruption of the SH2-B gene. Both male and female SH2-B(-/-) mice showed slight retardation in growth and… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…