SGLT inhibitors as new therapeutic tools in the treatment of diabetes.

  title={SGLT inhibitors as new therapeutic tools in the treatment of diabetes.},
  author={Rolf K. H. Kinne and Francisco Casta{\~n}eda},
  journal={Handbook of experimental pharmacology},
Recently, the idea has been developed to lower blood glucose blood glucose levels in diabetes by inhibiting sugar reabsorption sugar reabsorption in the kidney kidney . The main target is thereby the early proximal tubule proximal tubule where secondary active transport secondary active transport of the sugar is mediated by the sodium-D: -glucose D-glucose cotransporter SGLT2 SGLT2 . A model substance for the inhibitors inhibitors is the O-glucoside O-glucoside phlorizin phlorizin which… CONTINUE READING


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