SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.

  title={SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.},
  author={Jessica A Gasser and Hiroyuki Inuzuka and Alan C. W. Lau and Wenyi Wei and Rameen Beroukhim and A. C. Toker},
  journal={Molecular cell},
  volume={56 4},
Oncogenic mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide 3-kinase (PI3K), occur with high frequency in breast cancer. The protein kinase Akt is considered to be the primary effector of PIK3CA, although mechanisms by which PI3K mediates Akt-independent tumorigenic signals remain obscure. We show that serum and glucocorticoid-regulated kinase 3 (SGK3) is amplified in breast cancer and activated downstream of PIK3CA in a manner dependent on the phosphoinositide… CONTINUE READING
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