SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.

@article{YoshidaMoriguchi2013SGK196IA,
  title={SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.},
  author={Takako Yoshida-Moriguchi and Tobias Willer and Mary E Anderson and David Venzke and Tamieka Whyte and Francesco Muntoni and Hane Lee and Stanley F. Nelson and Liping Yu and Kevin P Campbell},
  journal={Science},
  year={2013},
  volume={341 6148},
  pages={896-9}
}
Phosphorylated O-mannosyl trisaccharide [N-acetylgalactosamine-β3-N-acetylglucosamine-β4-(phosphate-6-)mannose] is required for dystroglycan to bind laminin-G domain-containing extracellular proteins with high affinity in muscle and brain. However, the enzymes that produce this structure have not been fully elucidated. We found that glycosyltransferase-like… CONTINUE READING