SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone.

@article{Yang2017SGK1dependentEP,
  title={SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone.},
  author={Lei Yang and Gustavo Frindt and Florian Lang and Dietmar Kuhl and Volker Vallon and Lawrence G. Palmer},
  journal={American journal of physiology. Renal physiology},
  year={2017},
  volume={312 1},
  pages={
          F65-F76
        }
}
We examined renal Na and K transporters in mice with deletions in the gene encoding the aldosterone-induced protein SGK1. The knockout mice were hyperkalemic, and had altered expression of the subunits of the epithelial Na channel (ENaC). The kidneys showed decreased expression of the cleaved forms of the γENaC subunit, and the fully glycosylated form of the βENaC subunits when animals were fed a high-K diet. Knockout animals treated with exogenous aldosterone also had reduced subunit… CONTINUE READING
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