SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.


Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.

Citations per Year

291 Citations

Semantic Scholar estimates that this publication has 291 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{McCormick2005SGK1AR, title={SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.}, author={James McCormick and Vivek Bhalla and Alan C. Pao and David Pearce}, journal={Physiology}, year={2005}, volume={20}, pages={134-9} }