SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.

@article{Wang2001SGKII,
  title={SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.},
  author={J Wang and Pascal Barbry and Anita C. Maiyar and David J. Rozansky and Ajay Ku. Bhargava and M Leong and Gary L. Firestone and David Pearce},
  journal={American journal of physiology. Renal physiology},
  year={2001},
  volume={280 2},
  pages={
          F303-13
        }
}
The epithelial Na+ channel (ENaC) constitutes the rate-limiting step for Na+ transport across tight epithelia and is the principal target of hormonal regulation, particularly by insulin and mineralocorticoids. Recently, the serine-threonine kinase (SGK) was identified as a rapidly mineralocorticoid-responsive gene, the product of which stimulates ENaC-mediated Na+ transport. Like its close relative, protein kinase B (also called Akt), SGK's kinase activity is dependent on phosphatidylinositol 3… 
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SGK1 Regulation of Epithelial Sodium Transport
  • D. Pearce
  • Biology
    Cellular Physiology and Biochemistry
  • 2003
TLDR
SGK1 appears to have been implicated in membrane trafficking and possibly in the control of ion transport and cell volume in early single cell eukaryotes and in metazoan epithelia, it seems likely that SGK1 was adapted to the regulation of ions transport in response to hormonal and osmotic signals.
The role of SGK1 in hormone-regulated sodium transport
  • D. Pearce
  • Biology, Medicine
    Trends in Endocrinology & Metabolism
  • 2001
sgk: an essential convergence point for peptide and steroid hormone regulation of ENaC-mediated Na+ transport.
To study the role of sgk (serum, glucocorticoid-induced kinase) in hormonal regulation of Na+ transport mediated by the epithelial Na+ channel (ENaC), clonal cell lines stably expressing human sgk,…
Hypotonic induction of SGK1 and Na+ transport in A6 cells.
TLDR
Surprisingly, these results demonstrate that both hypertonic and hypotonic stimuli can induce SGK1 gene expression in a cell type-dependent fashion and lend support to the view thatSGK1 contributes to the defense of extracellular fluid volume and tonicity in amphibia by mediating a component of the hypotonic induction of distal nephron Na+ transport.
SGK1: Aldosterone-Induced Relay of Na+ Transport Regulation in Distal Kidney Nephron Cells
TLDR
This SGK1-Nedd4-2-ENaC pathway is the first direct link between aldosterone-induced transcriptional regulation and the function of the Na+transport machinery to be unravelled.
Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis
TLDR
Recent findings of SGK1’s involvement in Na+ transport in renal sodium reabsorption, hormone-stimulated salt appetite and fluid balance are focused on and the abnormalSGK1-mediated Na+ re absorption in hypertension, heart disease, edema with diabetes, and embryo implantation failure is discussed.
SGK regulation of renal sodium transport
  • Alan C Pao
  • Biology
    Current opinion in nephrology and hypertension
  • 2012
TLDR
The SGK kinases assume distinct roles in regulating Na+ transport in both proximal and distal elements of the kidney tubule, and future examination of the molecular mechanisms by which the SGK Kinases regulate specific substrates will inform the understanding of how these kinases contribute to the physiology of renal Na+ Transport.
The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport
Functional specificity of Sgk1 and Akt1 on ENaC activity.
TLDR
It is demonstrated that Akt does not increase ENaC function under basal conditions or after stimulation with aldosterone, insulin, or AVP, and that, in cells expressing both kinases, modulation ofENaC activity is mediated by Sgk1 but not by Akt1.
Sgk: an old enzyme revisited.
TLDR
In this issue of the JCI, Wulff and colleagues generated sgk1-deficient mice and examined the effects of dietary salt-restriction on renal water and electrolyte excretion.
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References

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