SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α

@article{Pastore2015SGK1PK,
  title={SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α},
  author={Donatella Pastore and David Della-Morte and Antonina Coppola and Barbara Capuani and Marco Lombardo and Francesca Pacifici and Francesca Ferrelli and Roberto Arriga and Caterina Mammi and Massimo Federici and Alfonso Bellia and Nicola Di Daniele and Manfredi Tesauro and Giulia Donadel and Daisuke Noto and Paolo Sbraccia and Giuseppe Sconocchia and Davide Lauro},
  journal={Cell Death and Disease},
  year={2015},
  volume={6},
  pages={e1890-}
}
Ceramide regulates several different cellular responses including mechanisms leading to apoptosis. Serum- and glucocorticoid-inducible protein kinase (SGK)-1 is a serine threonine kinase, which activates survival pathways in response to stress stimuli. Recently, we demonstrated an anti-apoptotic role of SGK-1 in human umbilical endothelial cells treated with high glucose. In the present study, since ceramide induces apoptosis by multiple mechanisms in diabetes and its complication such as… CONTINUE READING