SGE‐102: A novel therapy for refractory status epilepticus

@article{Reddy2013SGE102AN,
  title={SGE‐102: A novel therapy for refractory status epilepticus},
  author={K. Reddy and R. Reife and A. Cole},
  journal={Epilepsia},
  year={2013},
  volume={54}
}
Refractory status epilepticus (SE) has a mortality rate of up to 35%. Current treatment protocols for the treatment of SE begin with benzodiazepines and then proceed to conventional anticonvulsants. If seizures continue, SE is considered refractory (RSE) and treatment with anesthetic agents in undertaken. Twenty‐four h to 48 h after initiation of anesthesia with midazolam, pentobarbital or thiopental, or propofol, an attempt is made to wean the anesthetic. If this fails and seizures recur, SE… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Refractory status epilepticus: effect of treatment aggressiveness on prognosis.
Predictors of outcome in refractory status epilepticus.
Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit
Lack of anticonvulsant tolerance to the neuroactive steroid pregnanolone in mice.
...
1
2
...