SFTA2—A Novel Secretory Peptide Highly Expressed in the Lung—Is Modulated by Lipopolysaccharide but Not Hyperoxia

@inproceedings{Mittal2012SFTA2ANS,
  title={SFTA2—A Novel Secretory Peptide Highly Expressed in the Lung—Is Modulated by Lipopolysaccharide but Not Hyperoxia},
  author={Rashmi A. Mittal and Markus Hammel and Johannes Schwarz and Katharina M. Heschl and Nancy Bretschneider and Andreas W. Flemmer and Susanne Herber-Jonat and Melanie K{\"o}nigshoff and Oliver Eickelberg and Andreas Holzinger},
  booktitle={PloS one},
  year={2012}
}
Tissue-specific transcripts are likely to be of importance for the corresponding organ. While attempting to define the specific transcriptome of the human lung, we identified the transcript of a yet uncharacterized protein, SFTA2. In silico analyses, biochemical methods, fluorescence imaging and animal challenge experiments were employed to characterize SFTA2. Human SFTA2 is located on Chr. 6p21.33, a disease-susceptibility locus for diffuse panbronchiolitis. RT-PCR verified the abundance of… CONTINUE READING
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