SEX HORMONE BINDING GLOBULIN CAPACITY AS AN INDEX OF OESTROGENICITY OR ANDROGENICITY IN WOMEN ON ORAL CONTRACEPTIVE STEROIDS

@article{Makhzancy1979SEXHB,
  title={SEX HORMONE BINDING GLOBULIN CAPACITY AS AN INDEX OF OESTROGENICITY OR ANDROGENICITY IN WOMEN ON ORAL CONTRACEPTIVE STEROIDS},
  author={M. N. EL Makhzancy and Victor Wynn and DAPHNE M. Lawrence},
  journal={Clinical Endocrinology},
  year={1979},
  volume={10}
}
Plasma sex hormone binding globulin capacity (SHBC) measurements were evaluated in 125 women with a pre‐treatment mean value of 41 ± 17 nmol/l SHBG and during 3 to 36 cycles of either combination oestrogen and progestagen oral contraceptives (OC) or low progestagen‘mini’pills. An oestrogenic effect or significant elevation of SHBC was noted on combination OC or ethiriyl oestradiol with megestrol acetate, comparable with pregnancy levels (305 t 47 nmol/l SHBC or Volidan), whilst megestrol… 
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The progestagens studied had a weak androgen-like effect and lynestrenol also showed weak oestrogenic activity, as determined by their effects on serum proteins.
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