SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia.

@article{Cristbal2010SETBP1OI,
  title={SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia.},
  author={Ion Crist{\'o}bal and Francisco J Blanco and Laura Garc{\'i}a-Ort{\'i} and Nerea Marcotegui and Carmen Vicente and J. Rif{\'o}n and Francisco J. Novo and Eva Bandr{\'e}s and Mar{\'i}a Jos{\'e} Calasanz and Carmelo Bernabeu and Mar{\'i}a Dolores Odero},
  journal={Blood},
  year={2010},
  volume={115 3},
  pages={615-25}
}
Acute myeloid leukemias (AMLs) result from multiple genetic alterations in hematopoietic stem cells. We describe a novel t(12;18)(p13;q12) involving ETV6 in a patient with AML. The translocation resulted in overexpression of SETBP1 (18q12), located close to the breakpoint. Overexpression of SETBP1 through retroviral insertion has been reported to confer growth advantage in hematopoietic progenitor cells. We show that SETBP1 overexpression protects SET from protease cleavage, increasing the… CONTINUE READING
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