SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion.

@article{Schmidt2003SETACIN85RukAI,
  title={SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion.},
  author={Mirko H. H. Schmidt and Baihua Chen and Lisa M Randazzo and Oliver Bogler},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 14},
  pages={
          2845-55
        }
}
The adaptor protein SETA/CIN85/Ruk is involved in regulating diverse signal transduction pathways, including the internalization of tyrosine kinase receptors via the Cbl ubiquitin ligases, and attenuating PI3K activity by interaction with its regulatory subunit. Here we present evidence for a new aspect of SETA function, based on the initial observation… CONTINUE READING