SET domain proteins modulate chromatin domains in eu- and heterochromatin

  title={SET domain proteins modulate chromatin domains in eu- and heterochromatin},
  author={Thomas Jenuwein and Goetz Laible and Rainer Dorn and G. Regel. M. Reuter},
  journal={Cellular and Molecular Life Sciences CMLS},
The SET domain is a 130-amino acid, evolutionarily conserved sequence motif present in chromosomal proteins that function in modulating gene activities from yeast to mammals. Initially identified as members of the Polycomb- and trithorax-group (Pc-G and trx-G) gene families, which are required to maintain expression boundaries of homeotic selector (HOM-C) genes, SET domain proteins are also involved in position-effect-variegation (PEV), telomeric and centromeric gene silencing, and possibly in… CONTINUE READING
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