SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription.

@article{Li2013SETdomainBE,
  title={SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription.},
  author={Ting Li and Qiuhe Lu and Guolun Wang and Hao Xu and Huanwei Huang and Tao Cai and Biao Kan and Jianning Ge and Feng Shao},
  journal={EMBO reports},
  year={2013},
  volume={14 8},
  pages={
          733-40
        }
}
Transcription of rRNA genes (rDNAs) in the nucleolus is regulated by epigenetic chromatin modifications including histone H3 lysine (de)methylation. Here we show that LegAS4, a Legionella pneumophila type IV secretion system (TFSS) effector, is targeted to specific rDNA chromatin regions in the host nucleolus. LegAS4 promotes rDNA transcription, through its SET-domain (named after Drosophila Su(var)3-9, enhancer of zeste [E(z)], and trithorax [trx]) histone lysine methyltransferase (HKMTase… CONTINUE READING
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