SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium.

@article{Zhou2012SERPINA3KPA,
  title={SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium.},
  author={Tong Zhou and Rongrong Zong and Zhoujing Zhang and Chengpeng Zhu and Fangyu Pan and Xinye Xiao and Zhen Liu and Hui He and Jian-xing Ma and Zuguo Liu and Yueping Zhou},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 8},
  pages={5033-43}
}
PURPOSE We recently reported that SERPINA3K (SA3K), a member of the serine proteinase inhibitor (SERPIN) family, has antiangiogenic and anti-inflammatory activities. Here we investigated the antioxidant effects of SA3K in the corneal epithelium and the mechanism underlying its action. METHODS We established the oxidative stress models induced by hydrogen peroxide (H₂O₂) in cultured human corneal epithelial (HCE) cells and in rat corneal epithelium in vivo. Cell viability, flow cytometry, and… CONTINUE READING