SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.

@article{Sood2017SERINC5PI,
  title={SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.},
  author={Chetan Sood and Mariana Marin and A. I. Chande and Massimo Pizzato and Gregory B. Melikyan},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 14},
  pages={6014-6026}
}
The host proteins, SERINC3 and SERINC5, have been recently shown to incorporate into HIV-1 particles and compromise their ability to fuse with target cells, an effect that is antagonized by the viral Nef protein. Envelope (Env) glycoproteins from different HIV-1 isolates exhibit a broad range of sensitivity to SERINC-mediated restriction, and the mechanism… CONTINUE READING