SERF: a program for accessible surface area calculations.

  title={SERF: a program for accessible surface area calculations.},
  author={Darren R. Flower},
  journal={Journal of molecular graphics & modelling},
  volume={15 4},
The program SERF has been designed to facilitate the greater use of accessible surface area calculations in the analysis of protein structure, including analysis of surface area changes on binding and complexation. For comparative purposes, the program implements a number of alternative methods for calculating surface areas, including those that approximate residues by single spheres. Algorithmic details, comparative performance, and the software implementation of SERF are discussed.