SERCA pumps and human diseases.

@article{Hovnanian2007SERCAPA,
  title={SERCA pumps and human diseases.},
  author={Alain Hovnanian},
  journal={Sub-cellular biochemistry},
  year={2007},
  volume={45},
  pages={337-63}
}
Sarco(endo)plasmic reticulum (SER) Ca2+ ATPases represent a highly conserved family of Ca2+ pumps which actively transport Ca2+ from the cytosol to the SER against a large concentration gradient. In humans, 3 genes (ATP2A1-3) generate multiple isoforms (SERCAla,b, SERCA2a-c, SECA3a-f) by developmental or tissue-specific alternative splicing. These pumps differ by their regulatory and kinetic properties, allowing for optimized function in the tissue where they are expressed. They play a central… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…