SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

@article{Green2008SERCAPA,
  title={SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production},
  author={Kim N Green and Angelo Demuro and Yama Akbari and Brian D. Hitt and Ian F Smith and Ian Parker and Frank M Laferla},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={181},
  pages={1107 - 1116}
}
In addition to disrupting the regulated intramembraneous proteolysis of key substrates, mutations in the presenilins also alter calcium homeostasis, but the mechanism linking presenilins and calcium regulation is unresolved. At rest, cytosolic Ca(2+) is maintained at low levels by pumping Ca(2+) into stores in the endoplasmic reticulum (ER) via the sarco ER Ca(2+)-ATPase (SERCA) pumps. We show that SERCA activity is diminished in fibroblasts lacking both PS1 and PS2 genes, despite elevated… CONTINUE READING

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