SEQuel: improving the accuracy of genome assemblies

  title={SEQuel: improving the accuracy of genome assemblies},
  author={Roy Ronen and Christina Boucher and Hamidreza Chitsaz and Pavel A. Pevzner},
MOTIVATION Assemblies of next-generation sequencing (NGS) data, although accurate, still contain a substantial number of errors that need to be corrected after the assembly process. We develop SEQuel, a tool that corrects errors (i.e. insertions, deletions and substitution errors) in the assembled contigs. Fundamental to the algorithm behind SEQuel is the positional de Bruijn graph, a graph structure that models k-mers within reads while incorporating the approximate positions of reads into the… CONTINUE READING
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