SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis.

@article{Kim2007SEPS1PR,
  title={SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis.},
  author={Kee-Hong Kim and Yuan Gao and Ken Walder and Greg R. Collier and Joseph Arnold Skelton and Ahmed H. Kissebah},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={354 1},
  pages={127-32}
}
Selenoprotein S (SEPS1) is a novel endoplasmic reticulum (ER) resident protein and it is known to play an important role in production of inflammatory cytokines. Here, we show evidence that SEPS1 is stimulated by pharmacological ER stress agents in RAW264.7 macrophages as well as other cell types. Overexpression studies reveal a protective action of SEPS1 in macrophages against ER stress-induced cytotoxicity and apoptosis, resulting in promoting cell survival during ER stress. The protective… CONTINUE READING