SEPH, a Cdc7p orthologue from Aspergillus nidulans, functions upstream of actin ring formation during cytokinesis.

@article{Bruno2001SEPHAC,
  title={SEPH, a Cdc7p orthologue from Aspergillus nidulans, functions upstream of actin ring formation during cytokinesis.},
  author={Kenneth S. Bruno and Jennifer L. Morrell and John E. Hamer and Christopher J. Staiger},
  journal={Molecular microbiology},
  year={2001},
  volume={42 1},
  pages={3-12}
}
In the filamentous fungus, Aspergillus nidulans, multiple rounds of nuclear division occur before cytokinesis, allowing an unambiguous identification of genes required specifically for cytokinesis. As in animal cells, both an intact microtubule cytoskeleton and progression through mitosis are required for actin ring formation and contraction. The sepH gene from A. nidulans was discovered in a screen for temperature-sensitive cytokinesis mutants. Sequence analysis showed that SEPH is 42… CONTINUE READING