SEP-225289 serotonin and dopamine transporter occupancy: a PET study.

  title={SEP-225289 serotonin and dopamine transporter occupancy: a PET study.},
  author={Christine DeLorenzo and Sarah Lichenstein and Karen E. Schaefer and Judith Dunn and Randall Marshall and Lisa M Organisak and Jahnavi Kharidia and Brigitte Robertson and J. John Mann and Ramin V. Parsey},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={52 7},
UNLABELLED SEP-225289 is a novel compound that, based on in vitro potencies for transporter function, potentially inhibits reuptake at dopamine, norepinephrine, and serotonin transporters. An open-label PET study was conducted during the development of SEP-225289 to investigate its dopamine and serotonin transporter occupancy. METHODS Different single doses of SEP-225289 were administered to healthy volunteers in 3 cohorts: 8 mg (n = 7), 12 mg (n = 5), and 16 mg (n = 7). PET was performed… CONTINUE READING
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