SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

  title={SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing},
  author={Y. Cui and Huansha Yu and Xin Zheng and R. Peng and Q. Wang and Y. Zhou and R. Wang and J. Wang and B. Qu and N. Shen and Q. Guo and X. Liu and C. Wang},
  journal={PLoS Pathogens},
  • Y. Cui, Huansha Yu, +10 authors C. Wang
  • Published 2017
  • Biology, Medicine
  • PLoS Pathogens
  • Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2’3’-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease 7 (SENP7) interacted with and potentiated cGAS activation. The small ubiquitin-like modifier (SUMO) was conjugated onto the lysine residues 335, 372 and 382 of cGAS, which… CONTINUE READING
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