SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

@article{Ao2015SENP1DH,
  title={SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1$\alpha$},
  author={Qilin Ao and Wenjing Su and Shuang Guo and Lei Cai and Lei Huang},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1… 
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References

SHOWING 1-10 OF 37 REFERENCES
Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1α
TLDR
It is suggested that HIF-1α, stimulated by hypoxia, exerts a pivotal role in chemoresistance by G0/G1 arrest and might provide a potent tool to enhance paclitaxel effectiveness in treatment of human ovarian cancer.
BCL-xL Is a Target Gene Regulated by Hypoxia-inducible Factor-1α*
TLDR
HIF-1α-dependent BCL-xL overexpression may be an important mechanism by which HIF- 1α protects prostate cancer cells from apoptosis and leads to treatment resistance.
Targeting HIF-1 for cancer therapy
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
The role of hypoxia-inducible factors in tumorigenesis
TLDR
HIF regulates multiple aspects of tumorigenesis, including angiogenesis, proliferation, metabolism, metastasis, differentiation, and response to radiation therapy, making it a critical regulator of the malignant phenotype.
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer.
TLDR
HIF-1alpha expression is a strong independent prognostic marker in early stage cervical cancer and its influence on prognosis in patients with cervical cancer stage pT1b is investigated using immunohistochemistry.
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.
TLDR
It is shown that genes regulating cell death can be hypoxically induced and are overexpressed in clinical tumors and that BNIP3 is up-regulated in perinecrotic regions of the tumor.
Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
TLDR
It is concluded that HIF1α and HIF2α overexpression is a common event in NSCLC, which is related to the up-regulation of various angiogenic factors and with poor prognosis.
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