SELEX and dynamic combinatorial chemistry interplay for the selection of conjugated RNA aptamers.

@article{Bugaut2006SELEXAD,
  title={SELEX and dynamic combinatorial chemistry interplay for the selection of conjugated RNA aptamers.},
  author={Anthony Bugaut and Jean-Jacques Toulm{\'e} and Bernard Rayner},
  journal={Organic & biomolecular chemistry},
  year={2006},
  volume={4 22},
  pages={4082-8}
}
SELEX (for Systematic Evolution of Ligands by Exponential enrichment) has proven to be extraordinarily powerful for the isolation of DNA or RNA aptamers that bind with high affinity and specificity to a wide range of molecular targets. However, the modest chemical functionality of nucleic acids poses some limits on the versatility of aptamers as binders and catalysts. To further improve the properties of aptamers, additional chemical diversity must be introduced. The design of chemical… CONTINUE READING