SELECT: the Selenium and Vitamin E Cancer Prevention Trial: rationale and design

@article{Klein2000SELECTTS,
  title={SELECT: the Selenium and Vitamin E Cancer Prevention Trial: rationale and design},
  author={Eric A. Klein and Ian L. Thompson and STEVENA. Lippman and Poll Goodman and Demetrius Albanes and Philip R. Taylor and Charles Arthur Coltman},
  journal={Prostate Cancer and Prostatic Diseases},
  year={2000},
  volume={3},
  pages={145-151}
}
Prostate cancer is the commonest non-skin malignancy in the United States and has a substantial mortality rate despite the use of PSA-based screening. Furthermore, therapy for prostate cancer by surgery, radiotherapy or hormonal manipulation carries a significant risk of treatment-related morbidity. Recent analysis of secondary endpoints of several large-scale randomized prospective clinical trials for other malignancies has suggested that selenium or vitamin E may result in a decreased… CONTINUE READING
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