SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye.

  title={SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye.},
  author={F. Grus and V. Podust and K. Bruns and K. Lackner and Siyu Fu and E. Dalmasso and A. Wirthlin and N. Pfeiffer},
  journal={Investigative ophthalmology & visual science},
  volume={46 3},
  • F. Grus, V. Podust, +5 authors N. Pfeiffer
  • Published 2005
  • Medicine
  • Investigative ophthalmology & visual science
  • PURPOSE Protein and peptides in tears play an important role in ocular surface diseases. In previous studies, changes have been demonstrated in the electrophoretic protein profiles of patients with dry eye. The purpose of this work was to determine the usefulness of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) ProteinChip Array (Ciphergen Biosystems, Inc., Fremont, CA) technology for the automated analysis of proteins and peptides in tear fluid… CONTINUE READING
    160 Citations
    Alterations in the tear proteome of dry eye patients--a matter of the clinical phenotype.
    • 45
    iTRAQ quantitative proteomics in the analysis of tears in dry eye patients.
    • 74
    Applying Magnetic Bead Separation / MALDI-TOF Mass Spectrometry to Human Tear Fluid Proteome Analysis
    • 14
    • PDF
    Characterisation of human tear proteins using high-resolution mass spectrometry.
    • 93
    • PDF
    Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics.
    • 193
    Human tear peptide/protein profiling study of ocular surface diseases by SPE-MALDI-TOF mass spectrometry analyses
    • 4
    • PDF
    Tear proteomics in evaporative dry eye disease
    • 97
    • PDF
    Quantitation of 47 human tear proteins using high resolution multiple reaction monitoring (HR-MRM) based-mass spectrometry.
    • 33


    Analysis of Tear-Protein Patterns as a Diagnostic Tool for the Detection of Dry Eyes
    • 35
    The SELDI-TOF MS approach to proteomics: protein profiling and biomarker identification.
    • 530
    • PDF
    Methods for on-chip protein analysis.
    • 90
    Analysis of tear protein patterns by a neural network as a diagnostical tool for the detection of dry eyes
    • 30
    Two‐dimensional analysis of tear protein patterns of diabetic patients
    • 93
    Abnormal protein profiles in tears with dry eye syndrome.
    • 175