SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production.

@article{Stock1999SEC14dependentSI,
  title={SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production.},
  author={Stefanie Stock and Hiroko Hama and Daryll B. Dewald and Jon Y Takemoto},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 19},
  pages={
          12979-83
        }
}
The SEC14 gene in Saccharomyces cerevisiae encodes a phosphatidylinositol transfer protein required for secretory protein movement from the Golgi. Mutation of SAC1, a gene of unknown function, restores secretory flow in sec14-1(ts) strains. The existing model for the bypass of the sec14-1(ts) defect by sac1-22 involves stimulation of sphingolipid biosynthesis and, in particular, the synthesis of mannosyl-diinositolphosphoryl-ceramide with concomitant increases in Golgi diacylglycerol levels. To… CONTINUE READING
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