SEARCHING FOR FUNCTIONAL GENETIC VARIANTS IN NON‐CODING DNA

@article{Cobb2008SEARCHINGFF,
  title={SEARCHING FOR FUNCTIONAL GENETIC VARIANTS IN NON‐CODING DNA},
  author={J. Cobb and Cara J B{\"u}sst and S. Petrou and S. Harrap and J. Ellis},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2008},
  volume={35}
}
1 The search for DNA sequence variants for complex human polygenic conditions has been a strong focus of recent genetic research. While gene loci have been identified, few variants in the coding sequences of these genes have been found, suggesting that non‐coding sequence variation may underlie many complex conditions. 2 Non‐coding DNA harbours regulatory elements capable of making changes to gene expression. However, regulatory DNA sequences are currently difficult to recognize and their… Expand
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