SEA0400: a novel sodium-calcium exchange inhibitor with cardioprotective properties.

Abstract

The cardiac sodium-calcium exchanger (NCX) plays an important role in calcium homeostasis. It is the primary mechanism for removing calcium ions that enter myocytes through L-type calcium channels on a beat-to-beat basis. Its direction of transport is determined by the membrane potential and the ionic concentrations of Na+ and Ca2+, with the forward (or Ca2… (More)

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Cite this paper

@article{Lee2004SEA0400AN, title={SEA0400: a novel sodium-calcium exchange inhibitor with cardioprotective properties.}, author={Candace Y. W. Lee and Larry V. Hryshko}, journal={Cardiovascular drug reviews}, year={2004}, volume={22 4}, pages={334-47} }