SDZ CO 611: a highly potent glycated analog of somatostatin with improved oral activity.

@article{Albert1993SDZC6,
  title={SDZ CO 611: a highly potent glycated analog of somatostatin with improved oral activity.},
  author={Rainer Albert and Peter Marbach and Wilfried Bauer and Ulrich Briner and Gert Fricker and Christian Bruns and Janos Pless},
  journal={Life sciences},
  year={1993},
  volume={53 6},
  pages={
          517-25
        }
}
To obtain orally active octreotide (Sandostatin, SMS 201-995) analogs a new class of glycated somatostatin derivatives were synthesized by the Amadori reaction (Maillard reaction). The synthesis, chemical and biological characterization of a series of new compounds is described. These oligopeptides bind with high affinity to somatostatin receptors and… CONTINUE READING