SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells.

@article{Zernecke2005SDF1alphaCXCR4AI,
  title={SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells.},
  author={Alma Zernecke and Andreas Schober and Ilze Bot and Philipp von Hundelshausen and Elisa A Liehn and Barbara Moepps and Mathias Mericskay and Peter Gierschik and Erik A. L. Biessen and Christian Weber},
  journal={Circulation research},
  year={2005},
  volume={96 7},
  pages={784-91}
}
Recent evidence infers a contribution of smooth muscle cell (SMC) progenitors and stromal cell-derived factor (SDF)-1alpha to neointima formation after arterial injury. Inhibition of plaque area and SMC content in apolipoprotein E-deficient mice repopulated with LacZ+ or CXCR4-/- BM or lentiviral transfer of an antagonist reveals a crucial involvement of local SDF-1alpha and its receptor CXCR4 in neointimal hyperplasia via recruitment of BM-derived SMC progenitors. After arterial injury, SDF… CONTINUE READING
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