SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion.

@article{Hong2006SDF1AC,
  title={SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion.},
  author={Xin Hong and Feng Jiang and Steven N. Kalkanis and Zheng Gang Zhang and Xue-peng Zhang and Ana C deCarvalho and Mark Katakowski and Kevin R. Bobbitt and Tom Mikkelsen and Michael Chopp},
  journal={Cancer letters},
  year={2006},
  volume={236 1},
  pages={
          39-45
        }
}
  • Xin Hong, Feng Jiang, +7 authors Michael Chopp
  • Published in Cancer letters 2006
  • Biology, Medicine
  • Glioma cells produce vascular endothelial growth factor (VEGF) to induce vascularization and thereby supply the malignant tissue with oxygen and nutrients. However, little is known about the direct effects of VEGF on tumor cells. In this study, we investigate the ability of VEGF to promote proliferation and invasion of human glioma cells (U251n). Since the chemokine and its receptor, SDF-1/CXCR4, promote glioma cell proliferation and are up-regulated in human glioblastomas, we also tested the… CONTINUE READING

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