SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury.

@article{Hill2004SDF1I,
  title={SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury.},
  author={William D Hill and David C. Hess and Angeline Martin-Studdard and Jo J Carothers and Jianqing Zheng and David Hale and Manabu Maeda and Susan C Fagan and James E Carroll and Simon J. Conway},
  journal={Journal of neuropathology and experimental neurology},
  year={2004},
  volume={63 1},
  pages={84-96}
}
The chemokine stromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptor CXCR4 have been implicated in homing of stem cells to the bone marrow and the homing of bone marrow-derived cells to sites of injury. Bone marrow cells infiltrate brain and give rise to long-term resident cells following injury. Therefore, SDF-1 and CXCR4 expression patterns in 40 mice were examined relative to the homing of bone marrow-derived cells to sites of ischemic injury using a stroke model. Mice… CONTINUE READING
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