SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway.

@article{Li2012SDF1CXCR4SI,
  title={SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway.},
  author={Xuqi Li and Qingyong Ma and Qinhong Xu and Han Liu and Jianjun Lei and Wanxing Duan and Kruttika Narayan Bhat and Fengfei Wang and Erxi Wu and Zheng Wang},
  journal={Cancer letters},
  year={2012},
  volume={322 2},
  pages={
          169-76
        }
}
In our previous study, we found that blockade of SDF-1/CXCR4 signaling inhibits pancreatic cancer cell migration and invasion in vitro. However, the mechanism governing the downstream regulation of SDF-1/CXCR4-mediated invasion remains unclear. Here we report the role of SDF-1/CXCR4 in pancreatic cancer and the possible mechanism of SDF-1/CXCR4-mediated pancreatic cancer invasion. We show that there is a cross-talk between SDF-1/CXCR4 axis and non-canonical Hedgehog (Hh) pathway in pancreatic… CONTINUE READING
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